化合物管理

Since microplates became the storage and assay format of choice for drug discovery, there has always been a need to transfer samples from one plate format to another. This application note describes the automated reformatting of microplates, from 96 up to 1,563 wells.

This application note describes the easy automation of hit-picking and IC50 assay plate generation from tubes and microplates.

Dart NeuroScience specializes in the development of novel therapeutics targeting neurological disorders. In addition to performing multiple tasks on several Freedom EVO workstations, the company uses Tecan’s Fluent Laboratory Automation Solution to manage the throughput of assay plate generation.

The HP D300 Digital Dispenser has enabled Translational Drug Development in the USA to automate its workflows, increasing sample throughput and the number of cell line panels handled, as well as enhancing workflow efficiency.

The HP D300 Digital Dispenser is enabling researchers at the Columbia Genome Center’s High-Throughput Screening Facility to quickly and simply create dose-response curves for combinations of up to nine compounds, allowing rapid generation of EC 50 data for faster experimental progress.

GlaxoSmithKline’s quest for improved anti-malarial treatments has been revolutionized by the speed and reliability of the HP D300 Digital Dispenser. This innovative system has increased throughput for standard drug titrations and enabled combinations of candidate compounds to be tested much more easily.

Production of dose-response plates and cherry-picking are essential steps in early drug discovery to enable testing of many thousands of compounds. Researchers at Novartis are benefitting from the automated plate generation capabilities of two customized systems based on Freedom EVO 200 platforms, increasing sample throughput to over 10,000 compounds a day.

French pharmaceutical company Galderma specializes in the development of drugs for a variety of dermatological complaints, including acne, rosacea and psoriasis, and has chosen a customized Freedom EVO® 200 liquid handling workstation to manage its huge library of compounds used in high throughput screening.

Scientists at AstraZeneca UK, in partnership with Tecan, are developing a fully automated solubility screening platform, using a Freedom EVO 200 liquid handling workstation integrated with a tailor-made data capture system, a novel pH flow cell carrier and a small footprint HPLC system.